Michael Shermer (actual skeptic-not denier) compared AGW to evolution in that evolution brings together evidences from geology, paleontology, botany, zoology, biogeography, comparative anatomy and physiology, genetics, and so on. Climate scientists, similarly, use info from the environmental sciences, planetary geology, geophysics, glaciology, meteorology, chemistry, biology, ecology, and other disciplines.
I think this is why it's a difficult for some to accept, because they are looking for that "one study" that "proves" global warming, when no such thing exists. It's a failure to think in macro terms.