I am not sure if this works for later Prius models, but here is a trick on the 2004 to overide the GPS safety feature that won't let you change or add a destination while your car is in motion:
Go the volume setting on your screen (Dashboard Menu button to "Volume.") Then touch the top left portion of the screen, then bottom left, then top left again and then the bottom left one last time-- it will show you a new screen you've never seen before with lots of crazy 'buttons' (for the manufacturer.)
You then hold (touch) the "Override" button for a couple seconds 'till you hear a beep. Then you hit the back button in the upper right hand corner of the screen. Now you can use your GPS as if you were stopped! (By you, I mean your friend in the passenger seat of course... After all, you agreed to drive safely, didn't you?)
This is just a very helpful trick on road trips when you decide it'd be nice to find gas or food and don't want to pull over till you know where you're going. I hate when machines try to protect me from myself!

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